Accelerate and de-risk your early-stage targeted protein degradation project
Targeted protein degradation relies on bringing a ubiquitin ligase into close proximity with a target protein. As such, this modality does not rely on the target protein having a well-defined and accessible active site or functional binding pocket. This means that affinity screening methods based on ASMS or DEL can be used to identify ligands that may bind to any available pocket on the target protein.
But not all proteins are the same and not all protein targets are easily degraded.
What if you could rapidly assess the feasibility of a degrader project for your protein of interest? Welcome to CHARMED from Sygnature Discovery...