Medicinal Chemistry and Drug Discovery

Our medicinal chemistry teams are co-located and work seamlessly with analytical/separation science, computational chemistry, bioscience, pharmacology, DMPK, formulation and informatics teams to meet the challenge presented by projects at all phases in the drug discovery process (Hit validation, Hit Identification, Hit to lead, Lead Optimisation) across a full range of therapeutic areas, target classes and compound modalities.

High levels of investment in both our medicinal, synthetic and analytical chemistry capabilities in the form of equipment and data management systems together with the continual training and development of our team position Sygnature as an ideal partner for your chemistry project.


Our experts specialise in four key areas:

Medicinal Chemistry

Recognising the best path to an optimal drug profile requires experience and understanding. With Sygnature Discovery's team your drug discovery program is in safe hands.

Analytical Chemistry

Providing full confidence in the structure and purity of our molecules.

Synthetic Chemistry

Innovative synthetic chemistry makes a huge difference when seeking to generate novel patentable molecules with optimised properties.

High Throughput Chemistry

Our HTC lab has been efficiently producing small, diverse libraries for the European Lead Factory for the past 5 years.

Hit Finding

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"Discovering and developing a new drug is a complex and time-consuming endeavour. Pharmaceutical and biotechnology companies are under tremendous pressure to be first to market. Yet, many of the best-validated targets are in challenging protein classes with little precedence for small molecule ligand binding. This creates a significant hurdle for hit finding. A carefully devised strategy is, therefore, essential when looking for validated hit series with a good chance of being developed into drug-like compounds."

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Delivering for our customers - a proven track record

  • 48 pre-clinical candidates delivered
  • 27 already progressed to clinical trials (>50%)
  • Sygnature Discovery co-inventors named on >170 client patent applications
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