HIT SYNERGY at a glance

Multiple advanced technologies are united in one platform to solve the challenges of even the most challenging new target classes. Work with Sygnature Discovery's hit finding team to develop a strategy that leverages the components of the platform according to your specific goals.

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Comprehensive and integrated hit finding capabilities suitable for any target class

Watch our video to learn more about how HIT SYNERGY combines leading hit identification technologies with a strategy tailored to your target, goals and budget.

Engineer a winning hit ID strategy

HIT SYNERGY optimizes hit identification and validation using multiple approaches and expert input to ensure high-quality results.

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At the core of HIT SYNERGY is an active learning approach to screening

HIT SYNERGY's meticulously curated libraries, rich in scaffold diversity, are selected for their "sociability" – featuring numerous related molecules found in commercial databases. The platform's advanced computational methods can rapidly expand in 2D and 3D chemical space by selecting matching pharmacophores from available molecules. Its proprietary PRISM library, based around novel high Fsp3 scaffolds, delivers exclusive hit matter that is enabled for high throughput chemistry, designed with computational selection from the fully enumerated scaffold library of 17 million analogues.

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Generate high-quality, validated hits uncovering different binding sites, MOAs and diverse chemo-types

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HIT SYNERGY’s affinity screening methods identify high-affinity binders agnostic of binding site. Useful for identifying allosteric pockets and enabling targeted protein degradation.
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HIT SYNERGY's fragment library supports a tailored FBDD approach. Access a range of biophysical & protein structure platforms.
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A purpose-built automation facility with state-of-the-art HighRes automation includes compound management capabilities which incorporate high fidelity LIMs tracking and analysis.
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Cutting-edge computational technology allows efficient ligand-based and/or docking screens of very large real and virtual commercial databases. Consistently delivers hits against challenging protein targets.

Why choose HIT SYNERGY for hit ID?

While many CROs address individual aspects of a hit ID strategy, HIT SYNERGY unites cutting-edge technologies and expertise into a single, integrated platform focused on developing well-validated chemical starting points to facilitate a smooth optimisation to candidate drugs.

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Tailored Strategies
Comprehensive Screening Cascades
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Proven Track Record

Delivering for our customers - a proven track record

  • 48 pre-clinical candidates delivered
  • 27 already progressed to clinical trials (>50%)
  • Sygnature Discovery co-inventors named on >170 client patent applications
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Discover how HIT SYNERGY supports hit ID success and beyond, today

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