“In a lead optimization program, there is no substitute for experience. Medicinal chemists and other drug discovery specialists who have been working in the field for years are well placed to know what to look for – and what to avoid. Making the best use of the modern tools at their disposal, allied to skills and expertise development across multiple lead optimization programs in the past, will make success more likely.”
We have created a unique collaborative environment to enable our multidisciplinary drug discovery teams to efficiently explore and optimize Structure Activity Relationships (SAR). We like to interact with customers in the same highly collaborative mode, whilst always seeking to proactively suggest well-reasoned solutions and strategies for project progression.
By working with us you will have access to:
Design-Make-Test-Evaluate
Our high efficiency Design–Make–Test-Evaluate cycle, as a result of team integration and co-localization, which rapidly generates high quality data for expert evaluation.
Scale-Up Capability
Our scale-up capability that allows rapid delivery of non-GLP safety assessment batch and transfer of a robust route to a Contract Manufacturing Organization for GMP synthesis.
Track Record
A strong track record - we have delivered 40 high-quality clinical candidates for clients, a large proportion of which have already progressed to human dosing.
The Team
Our experienced teams can avoid common pitfalls and interrogate the available data, providing innovative solutions to the challenges encountered.
A History of Innovation
Since our founding in 2004, the integrated drug discovery team at Sygnature Discovery has delivered over 40 preclinical compounds and 22 clinical compounds. Our scientists are named on over 160 customer patent applications.
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