Postgraduate Symposium; Synthetic Organic Chemistry

Join our celebration of science, as we showcase some of the best synthesis and design from applicant research groups, learn about how we can add innovation into our client programmes at Sygnature, and hear from Key note speaker, Dr Paul Leeson, on the importance of molecular properties in drug design.

Success in our industry relies on scientific excellence, and we would like to encourage the next generation of medicinal chemists by inviting applications from final year organic chemistry Ph.D students and Post Doc’s for the inaugural Sygnature Discovery Synthetic Organic Chemistry Postgraduate Symposium taking place on Tuesday 19th July, 9:00am - 17:00pm BST. To get acquainted with the speakers ahead of time, please check out their bio's via the 'Meet the Speakers'.

Meet the Speakers

Agenda:

08:45am - Welcoming Remarks  

09:00 - 09:20am - Stuart Astle (1);

  •  University of Oxford, Jonathan Burton: The Enantioselective Total Synthesis of Sealutomicin C

09:25 - 09:45am - Charlotte Lorton (2);

  • University of Paris-Saclay Institut de Chimie des Substances CNRS, Arnaud Voituriez: Development of new methodologies in asymmetric redox phosphine organocatalysis. Current Position: Post Doc John Bower, University of Liverpool

09:50 - 10:10am - Daniel Kovari (3);

  •  University of Birmingham, Liam Cox: Spiro morpholines as starting points for diversity library synthesis

10:15 - 10:35am - Rebecca Craik (4);

  •  St. Andrews University, Andrew Smith: Isochalcogenourea Catalysed Enantioselective α-Alkylation of Schiff Base Glycine Derivatives

10:40 - 11:00am - Break 

11:00 - 11:20am - Matthew Williams (5);

  •  University of Glasgow, Alistair Boyer: A Modular One-Pot Approach Towards Highly Functionalised 3-Azapyrroles

11: 25 - 11:45am - Tom D'Arcy (6);

  •  University of Loughborough, Benjamin Buckley: Enantioselective Synthesis of Dimerised ortho-quinols via Oxaziridinium Catalysed Phenol Dearomatization

11:50 - 12:35pm - Greg Iacobini;

  •  Sygnature Discovery, Development of selective CAMK1 inhibitors as in vivo tool compounds in triple-negative breast cancer models

12:50 - 13:50pm - Flash Talks & Lunch 

13:50 - 14:00pm - Break 

14:00 - 14:20pm - Giordaina Hartley (7);

  •  University of York, Peter O’Brien: Stereoselective α- and β-functionalisation of cyclic sulfoximines

14:25 - 14:45pm - James Bowen (8);

  •  University of Bristol, Chris Willis: Ambruticins: Tetrahydropyran Ring Formation and Total Synthesis

14:50 - 15:10pm - Joe Higham (9);

  •  Imperial College London, James Bull: Amine‐Catalyzed Copper‐Mediated C−H Sulfonylation of Benzaldehydes via a Transient Imine Directing Group

15:15 - 15:35pm - Laura Winfrey (10);

  •  University of Leicester, Alexander Pulis: B(C6F5)3-Catalysed C3 Alkylation of Indoles and Oxindoles

15:40 - 16:00pm - Break & Voting Session 

16:00 - 16:50pm - Paul Leeson

  •  Paul Leeson Consulting, "Drug-like" Properties: Which are useful and which are not?

16:50 - 17:00pm - Awards & Close